Arizona Cardinals vs San Francisco 49ers Recap

The Arizona Cardinals vs San Francisco 49ers rivalry is an NFL NFC West division rivalry. Both teams meet twice each regular season, and their games are important in the race for the NFC West title. The rivalry has featured many memorable matchups over the years.

Cardinals vs 49ers Rivalry Summary

When was the first Cardinals vs 49ers game?

• The first meeting was played on November 18, 1951. The Cardinals won 27-21.

Who won the latest meeting?

• The San Francisco 49ers defeated the Arizona Cardinals 41-22 on November 16, 2025.

When is the next Cardinals vs 49ers game?

• The next game is scheduled for September 27, 2026, at Levi’s Stadium in Santa Clara, California. Kickoff is at 4:05 p.m. ET on FOX.

Where do the teams play their home games?

• The 49ers play at Levi’s Stadium, while the Cardinals play at State Farm Stadium.

How many times have the Cardinals and 49ers played?

• The two teams have met 69 times in the regular season.

Who leads the all-time series?

• The San Francisco 49ers lead the series 38-31.

What is the largest victory in the rivalry?

• The 49ers’ biggest win was 50-14 in 2003. The Cardinals’ biggest win was 47-7 in 2015.

What are the most points scored by each team?

• The 49ers scored 50 points in 2003. The Cardinals scored 47 points in both 2015 and 2024.

What is the longest winning streak in the rivalry?

• The 49ers have had three separate five-game winning streaks (1980-1987, 1993-2002, and 2009-2011). The Cardinals’ longest winning streak is eight games from 2015 to 2018.

What is the current winning streak?

• The San Francisco 49ers have the current winning streak at two games, beginning in 2025.

The Arizona Cardinals and San Francisco 49ers share one of the NFC West’s longest-running rivalries. With 69 meetings and the 49ers holding a 38-31 series lead, every matchup remains an important division game for both teams and their fans.