2028 San Francisco 49ers Season Schedule
The San Francisco 49ers upcoming football game schedule for 2028 NFL season and likely conclude through 2029 playoffs rounds. The formula of home and away 17-game schedule are set according to their official sources and subject to change.
Below is a full list of San Francisco’s opponents with time, date, location, TV channel and predictions for each of the games.
2028-29 San Francisco 49ers Regular Season
| Week | Date | Opponents | Time (ET) | Predictions |
| 1 | TBD | at Pittsburgh Steelers | TBD | |
| 2 | TBD | at Los Angeles Rams | TBD | |
| 3 | TBD | New York Giants | TBD | |
| 4 | TBD | Arizona Cardinals | TBD | |
| 5 | TBD | Dallas Cowboys | TBD | |
| 6 | TBD | at Cleveland Browns | TBD | |
| 7 | TBD | at Minnesota Vikings | TBD | |
| 8 | TBD | Cincinnati Bengals | TBD | |
| 9 | TBD | BYE | TBD | |
| 10 | TBD | at Jacksonville Jaguars | TBD | |
| 11 | TBD | Tampa Bay Buccaneers | TBD | |
| 12 | TBD | at Seattle Seahawks | TBD | |
| 13 | TBD | at Philadelphia Eagles | TBD | |
| 14 | TBD | Seattle Seahawks | TBD | |
| 15 | TBD | at Arizona Cardinals | TBD | |
| 16 | TBD | Baltimore Ravens | TBD | |
| 17 | TBD | at Washington Commanders | TBD | |
| 18 | TBD | Los Angeles Rams | TBD |