NFL Week 9 Picks, Odds & Predictions: Bills Outgun Chiefs in AFC Showdown

As the 2025 NFL season hits its mid-point, playoff races are starting to heat up across both conferences. Several powerhouse teams — including the Colts, Eagles, and Packers — are separating themselves from the pack, while a few underdogs are fighting to stay alive in the hunt. Week 9 offers a stacked lineup filled with divisional battles, high-stakes matchups, and prime-time showdowns that could shape the postseason picture. From Baltimore’s Thursday night clash in Miami to Monday night’s big stage in Dallas, here are our game-by-game picks, score predictions, and storylines to watch.

Week 9 could be the turning point for several teams chasing playoff contention. The Ravens and Packers look poised to continue their dominance, while the Bills and Eagles remain legitimate Super Bowl contenders. Expect fireworks in Buffalo, steady control from Indianapolis, and statement wins from Detroit and Green Bay. With every game now carrying postseason weight, the margin for error is shrinking fast — and Week 9 might just be the week that separates the contenders from the pretenders.

NFL Week 9 Predictions & Game Picks (2025 Season)

Thursday, October 30, 2025

Baltimore Ravens at Miami Dolphins

• 8:15 p.m. ET | Prime Video
• Hard Rock Stadium, Miami Gardens, FL
• Line: BAL -7.5 | O/U: 50.5

Prediction: Baltimore’s defense overwhelms Miami’s offense. Lamar Jackson delivers a strong prime-time performance.

Pick: Ravens 31, Dolphins 20

Sunday, November 2, 2025

Chicago Bears at Cincinnati Bengals

• 1:00 p.m. ET | CBS
• Paycor Stadium, Cincinnati, OH
• Line: CHI -2.5 | O/U: 50.5

Prediction: Chicago’s offense stays balanced; Cincinnati can’t contain the Bears’ ground game.

Pick: Bears 27, Bengals 23

Minnesota Vikings at Detroit Lions

• 1:00 p.m. ET | FOX
• Ford Field, Detroit, MI
• Line: DET -8.5 | O/U: 48.5

Prediction: The Lions flex NFC North control with another home win.

Pick: Lions 31, Vikings 17

Carolina Panthers at Green Bay Packers

• 1:00 p.m. ET | FOX
• Lambeau Field, Green Bay, WI
• Line: GB -13.5 | O/U: 44.5

Prediction: Jordan Love keeps Green Bay rolling in the cold.

Pick: Packers 30, Panthers 13

Los Angeles Chargers at Tennessee Titans

• 1:00 p.m. ET | CBS
• Nissan Stadium, Nashville, TN
• Line: LAC -9.5 | O/U: 43.5

Prediction: Herbert and the Chargers offense dominate early and coast to a win.

Pick: Chargers 28, Titans 10

Atlanta Falcons at New England Patriots

• 1:00 p.m. ET | CBS
• Gillette Stadium, Foxborough, MA
• Line: NE -4.5 | O/U: 44.5

Prediction: The Patriots’ defense and home field advantage make the difference.

Pick: Patriots 24, Falcons 17

San Francisco 49ers at New York Jets

• 1:00 p.m. ET | CBS
• MetLife Stadium, East Rutherford, NJ
• Line: SF -2.5 | O/U: 48.5

Prediction: McCaffrey leads the charge as San Francisco edges out a close one.

Pick: 49ers 26, Jets 20

Indianapolis Colts at Pittsburgh Steelers

• 1:00 p.m. ET | CBS
• Acrisure Stadium, Pittsburgh, PA
• Line: IND -3.5 | O/U: 50.5

Prediction: Richardson and Taylor keep the Colts in front in a tight AFC battle.

Pick: Colts 27, Steelers 24

Denver Broncos at Houston Texans

• 1:00 p.m. ET | FOX
• NRG Stadium, Houston, TX
• Line: HOU -1.5 | O/U: 39.5

Prediction: A defensive slugfest — Denver pulls off a gritty win on the road.

Pick: Broncos 20, Texans 17

Jacksonville Jaguars at Las Vegas Raiders

• 4:05 p.m. ET | FOX
• Allegiant Stadium, Las Vegas, NV
• Line: JAX -2.5 | O/U: 44.5

Prediction: Lawrence and Etienne lead Jacksonville to a bounce-back win.

Pick: Jaguars 28, Raiders 21

New Orleans Saints at Los Angeles Rams

• 4:05 p.m. ET | FOX
• SoFi Stadium, Inglewood, CA
• Line: LAR -14.5 | O/U: 43.5

Prediction: Stafford and Kupp torch the Saints’ secondary.

Pick: Rams 34, Saints 13

Kansas City Chiefs at Buffalo Bills

• 4:25 p.m. ET | CBS
• Highmark Stadium, Orchard Park, NY
• Line: KC -2.5 | O/U: 52.5

Prediction: Mahomes vs. Allen delivers fireworks again — this time Buffalo wins late.

Pick: Bills 33, Chiefs 30

Seattle Seahawks at Washington Commanders

• 8:20 p.m. ET | NBC
• Northwest Stadium, Landover, MD
• Line: SEA -2.5 | O/U: 47.5

Prediction: Geno Smith shines in prime time; Seahawks control the pace.

Pick: Seahawks 27, Commanders 19

Monday, November 3, 2025

Arizona Cardinals at Dallas Cowboys

• 8:15 p.m. ET | ABC, ESPN
• AT&T Stadium, Arlington, TX
• Line: DAL -2.5 | O/U: 53.5

Prediction: Prescott and Lamb put on a show in a high-scoring home win.

Pick: Cowboys 34, Cardinals 28