NFL Week 7 Odds & Game Previews: Key Matchups, Lines, and Early Predictions

The 2025 NFL season keeps heating up as we roll into Week 7, and this slate brings everything fans could want — rivalry showdowns, international action from London, and a Monday night doubleheader to close it out in style. Let’s break down the odds and what to watch for in each matchup.

Thursday Night Football: Pittsburgh Steelers @ Cincinnati Bengals

• Paycor Stadium, Cincinnati, OH
• Line: PIT -6.5 | O/U: 41.5

The Steelers are favored on the road as their defense continues to dominate. Cincinnati’s offense has struggled to find rhythm, and Pittsburgh’s pass rush could make it another long night for the Bengals. Expect a physical AFC North battle — but the under might look tempting.

London Game: Los Angeles Rams @ Jacksonville Jaguars

• Wembley Stadium, London, England

The NFL heads overseas again! The Rams travel to London to take on a young Jaguars team that’s looking to bounce back from recent struggles. With Matthew Stafford slinging and Trevor Lawrence leading the Jags, this could be one of the more entertaining matchups of the week — even without betting lines yet, expect a close one.

New Orleans Saints @ Chicago Bears

• Soldier Field, Chicago, IL
• Line: CHI -5.5 | O/U: 42.5

The Bears are gaining confidence behind their improved offense. Chicago’s home-field advantage at windy Soldier Field might make things tough for New Orleans. The Saints’ defense will need to step up big to cover the spread.

Miami Dolphins @ Cleveland Browns

• Huntington Bank Field, Cleveland, OH
• Line: MIA -7.5 | O/U: 40.5

Miami’s explosive offense remains hard to stop. The Browns’ defense is strong, but unless they find consistency under center, they might not keep up with Tua and company. Dolphins look like solid road favorites here.

New England Patriots @ Tennessee Titans

• Nissan Stadium, Nashville, TN
• Line: NE -6.5 | O/U: 38.5

A low total reflects two teams leaning on defense. The Patriots are favorites, but Tennessee’s ground game could test them. Expect a slow, physical contest where field position matters most.

Las Vegas Raiders @ Kansas City Chiefs

• Arrowhead Stadium, Kansas City, MO
• Line: KC -12.5 | O/U: 45.5

Patrick Mahomes and the Chiefs are massive favorites at home, and for good reason. Kansas City rarely slips up against division rivals, especially in front of the Arrowhead crowd. Raiders will need a miracle to pull off the upset.

Philadelphia Eagles @ Minnesota Vikings

• U.S. Bank Stadium, Minneapolis, MN
• Line: PHI -7.5 | O/U: 40.5

The Eagles look like one of the NFL’s most complete teams. Minnesota’s offense can score, but Philly’s defense and rushing attack give them the edge. Expect a statement win for the birds.

Carolina Panthers @ New York Jets

• MetLife Stadium, East Rutherford, NJ
• Line: NYJ -3.5 | O/U: 50.5

High total alert! The Jets are slight favorites at home, but both teams have shown flashes of offensive firepower. This could turn into a surprise shootout.

New York Giants @ Denver Broncos

• Empower Field at Mile High, Denver, CO
• Line: DEN -14.5 | O/U: 44.5

That’s a huge spread. Denver’s altitude and strong defense make life difficult for visiting teams, but 14.5 points is a lot to give up. The Giants might sneak a cover even if the Broncos win comfortably.

• Indianapolis Colts @ Los Angeles Chargers
• SoFi Stadium, Inglewood, CA

Two unpredictable teams meet in prime time. The Chargers’ offense can light it up, but Indy’s resilience keeps them competitive. No line yet — but this could quietly be one of the week’s best games.

Washington Commanders @ Dallas Cowboys

• AT&T Stadium, Arlington, TX
• Line: DAL -4.5 | O/U: 49.5

Classic NFC East rivalry. Dallas is favored at home, but Washington’s improving offense makes this one interesting. The over could be worth a look if both QBs get hot.

Green Bay Packers @ Arizona Cardinals

• State Farm Stadium, Glendale, AZ
• Line: GB -3.5 | O/U: 50.5

Green Bay is a slight favorite, but Arizona has played tough at home. Expect plenty of offense with two teams willing to push the tempo — this could easily hit the over.

Atlanta Falcons @ San Francisco 49ers

• Levi’s Stadium, Santa Clara, CA
• Line: SF -4.5 | O/U: 48.5

The 49ers at home are always dangerous, and Atlanta’s defense may not keep pace. San Francisco should control the game if they establish the run early.

Monday Night Football #1: Tampa Bay Buccaneers @ Detroit Lions

• Ford Field, Detroit, MI
• Line: DET -2.5 | O/U: 47.5

This is one to watch. Detroit has been solid at home, but Tampa Bay’s defense has shown it can hang with anyone. Expect a tight, entertaining finish.

Monday Night Football #2: Houston Texans @ Seattle Seahawks

• Lumen Field, Seattle, WA
• Line: SEA -4.5 | O/U: 47.5

After Houston’s stunning 44–10 win over the Ravens, they’ll face a tough test in Seattle’s loud environment. The Seahawks are favored, but the Texans’ confidence is sky-high — upset alert potential.

• Early Week 7 Picks to Watch
• Best Bet: Philadelphia -7.5 @ Minnesota
• High-Scoring Game Alert: Packers vs. Cardinals (O/U 50.5)
• Potential Upset: Texans over Seahawks
• London Spotlight: Rams vs. Jaguars in a coin-flip matchup

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