NFL Week 13 Picks & Predictions
Week 13 arrives with playoff races tightening across the AFC and NFC. Several matchups this week involve teams fighting for Wild Card positioning, division leads, or simply survival. Using the ESPN odds you’ve listed, here’s a full breakdown of every game – who wins, why, and what it means for the postseason picture.
Thursday – NOVEMBER 27, 2025
Green Bay Packers @ Detroit Lions
- Line: DET -3 | O/U: 49.5
- Pick: Lions 27, Packers 23
Why:
Detroit continues to play strong at home inside Ford Field, and the Packers’ defense has been inconsistent against explosive passing teams. The Lions’ balance on offense gives them the edge.
Playoff angle:
- Lions: Win keeps them in NFC North control.
- Packers: Loss pushes them closer to Wild Card desperation.
Kansas City Chiefs @ Dallas Cowboys
- Line: KC -3.5 | O/U: 51.5
- Pick: Chiefs 30, Cowboys 27
Why:
Even on the road, Kansas City’s offense has been more stable late in the year. Dallas usually plays well at home, but their defense against elite QBs has been shaky.
Playoff angle:
- Chiefs: Win strengthens AFC West lead.
- Cowboys: Risk falling behind in NFC Wild Card if they drop this one.
Cincinnati Bengals @ Baltimore Ravens
- Line: BAL -7.5 | O/U: 51.5
- Pick: Ravens 31, Bengals 20
Why:
Baltimore at M&T Bank Stadium is one of the league’s toughest environments. Cincinnati’s injuries and defensive regression leave them vulnerable.
Playoff angle:
- Ravens: Winning keeps them in the AFC No.1 seed chase.
- Bengals: A loss badly damages their Wild Card odds.
SATURDAY – NOVEMBER 29, 2025
Chicago Bears @ Philadelphia Eagles
- Line: PHI -7 | O/U: 44.5
- Pick: Eagles 26, Bears 16
Why:
Philadelphia is the far more complete team, especially at home. Chicago’s young offense shouldn’t be expected to match the Eagles in a road environment.
Playoff angle:
- Eagles: Win keeps NFC East pressure high.
- Bears: Another loss ends remaining playoff hopes.
SUNDAY – NOVEMBER 30, 2025
San Francisco 49ers @ Cleveland Browns
- Line: SF -6 | O/U: 40.5
- Pick: 49ers 23, Browns 13
Why:
San Francisco’s defense gives them a big advantage in a low-scoring matchup. Cleveland’s offense lacks the explosiveness needed to keep pace.
Playoff angle:
- 49ers: Stay atop NFC seeding race.
- Browns: Loss makes AFC Wild Card path tighter.
Jacksonville Jaguars @ Tennessee Titans
- Line: JAX -6.5 | O/U: 41.5
- Pick: Jaguars 24, Titans 17
Why:
Tennessee struggles to score consistently. Jacksonville’s passing game should take advantage of a soft Titans secondary.
Playoff angle:
- Jaguars: Win keeps them in AFC South control.
- Titans: A loss likely eliminates their playoff chances.
Houston Texans @ Indianapolis Colts
- Line: IND -3.5 | O/U: 44.5
- Pick: Texans 27, Colts 24 (Upset)
Why:
Even with Indy favored at home, Houston has shown better offensive balance and more upside in close games.
Playoff angle:
- Texans: Big boost in AFC Wild Card race.
- Colts: Loss hurts division tiebreakers.
New Orleans Saints @ Miami Dolphins
- Line: MIA -6 | O/U: 41.5
- Pick: Dolphins 28, Saints 17
Why:
Miami’s speed on offense is too much for New Orleans, especially in warm home conditions.
Playoff angle:
- Dolphins: Remain solidly in AFC playoff picture.
- Saints: Could drop from NFC Wild Card contention.
Atlanta Falcons @ New York Jets
- Line: ATL -2.5 | O/U: 39.5
- Pick: Falcons 20, Jets 16
Why:
The Jets’ offense has been inconsistent, while Atlanta’s run game gives them a safer floor.
Playoff angle:
- Falcons: Win keeps NFC South tension alive.
- Jets: Near playoff elimination with another loss.
Arizona Cardinals @ Tampa Bay Buccaneers
- Line: TB -2.5 | O/U: 45.5
- Pick: Buccaneers 23, Cardinals 20
Why:
Arizona has explosive moments, but Tampa Bay at home with better defensive stability gives them the edge.
Playoff angle:
- Buccaneers: Win keeps them in NFC Wild Card hunt.
- Cardinals: Loss puts them behind too many NFC teams.
Los Angeles Rams @ Carolina Panthers
- Line: LAR -10 | O/U: 46.5
- Pick: Rams 31, Panthers 14
Why:
Carolina is still rebuilding. The Rams’ offense and their pass rush should control this game easily.
Playoff angle:
- Rams: Win strengthens NFC Wild Card standing.
- Panthers: Building for the future.
Minnesota Vikings @ Seattle Seahawks
- Line: SEA -8.5 | O/U: 42.5
- Pick: Seahawks 28, Vikings 18
Why:
Seattle at home is a huge advantage, and Minnesota’s defense struggles in loud, high-pressure environments.
Playoff angle:
- Seahawks: Win keeps them firmly in NFC Wild Card.
- Vikings: Loss could knock them out of realistic playoff chances.
Buffalo Bills @ Pittsburgh Steelers
- Line: BUF -4 | O/U: 47.5
- Pick: Bills 27, Steelers 21
Why:
Buffalo’s offense is too dynamic for Pittsburgh to keep up with. Steelers stay close, but not quite enough.
Playoff angle:
- Bills: AFC East lead stays alive.
- Steelers: Loss complicates playoff math.
Las Vegas Raiders @ Los Angeles Chargers
- Line: LAC -9.5 | O/U: 41.5
- Pick: Chargers 30, Raiders 17
Why:
The Chargers’ offense has been stronger and more explosive, while the Raiders struggle to finish drives.
Playoff angle:
- Chargers: Win keeps them in AFC Wild Card chase.
- Raiders: Nearly eliminated with another defeat.
Denver Broncos @ Washington Commanders
- Line: DEN -6.5 | O/U: 43.5
- Pick: Broncos 24, Commanders 16
Why:
Denver’s defense leads the matchup, and Washington lacks the offensive depth to challenge consistently.
Playoff angle:
- Broncos: Win keeps postseason hopes alive.
- Commanders: Moving further out of NFC contention.
MONDAY – DECEMBER 1, 2025
New York Giants @ New England Patriots
- Line: NE -7.5 | O/U: 47.5
- Pick: Patriots 24, Giants 20
Why:
New England’s defense plays much better at home, and the Giants’ offensive struggles continue.
Playoff angle:
- Patriots: Still technically alive in AFC race.
- Giants: Rebuilding, playoff odds minimal.
Week 13 feels like the true turning point of the season. Every game now has playoff weight, whether it’s a division showdown like Packers-Lions, a heavyweight battle such as Chiefs–Cowboys, or a survival matchup for teams fighting to stay alive in December. The gap between contenders and pretenders grows sharper this week, and several teams may find their postseason paths closing quickly if they fall short.
From top seeds trying to secure home-field advantage to Wild Card hopefuls clinging to every tiebreaker, this week offers meaningful football across the board. As December football begins, every snap matters – and after Week 13, the playoff picture will look clearer than ever.