NFL Week 11 Picks & Predictions (2025 Season)

The 2025 NFL regular season rolls into Week 11, and the playoff picture is starting to take shape. With several key divisional matchups and international action in Madrid, this week promises excitement from start to finish. Based on ESPN Bet odds, team form, and Week 10 results, here are our game-by-game picks and predictions for Week 11.

New York Giants @ New England Patriots (Thursday, November 13, 2025)

• 7:15 AM ET | Prime Video | Gillette Stadium, MA
• Line: NE -10.5 | O/U: 44.5
• Last Week: NYG lost 24–20 at Chicago; NE beat TB 28-23.
• Prediction: The Patriots are trending upward after a solid win over Tampa Bay. Baker Mayfield’s efficiency and TreVeyon Henderson’s ground game give them the edge against a shaky Giants team.
• Pick: Patriots 27, Giants 13
• Best Bet: Patriots -10.5 | Lean: Under 44.5

Sunday, November 16, 2025

Washington Commanders @ Miami Dolphins

• 8:30 PM ET | NFL Network, NFL+ | Madrid, Spain
• Line: MIA -2.5 | O/U: 47.5
• Last Week: Washington lost 44-22 to Detroit; Miami dominated Buffalo 30–13.
• Prediction: The Dolphins looked explosive with De’Von Achane and Jaylen Waddle leading the charge. Washington’s defense won’t slow down this Miami attack overseas.
• Pick: Dolphins 31, Commanders 21
• Best Bet: Miami -2.5 | Lean: Over 47.5

Carolina Panthers @ Atlanta Falcons

• 12:00 AM ET | FOX | Atlanta, GA
• Line: ATL -3.5 | O/U: 42.5
• Last Week: Carolina lost 17-7 vs New Orleans; Atlanta fell 31–25 (OT) to Indianapolis.
• Prediction: Atlanta’s passing game continues to show signs of life with Drake London, while Carolina’s offense remains lifeless.
• Pick: Falcons 23, Panthers 16
• Best Bet: Atlanta -3.5 | Lean: Under 42.5

Tampa Bay Buccaneers @ Buffalo Bills

• 12:00 AM ET | CBS | Orchard Park, NY
• Line: BUF -5.5 | O/U: 49.5
• Last Week: TB lost to NE 28-23; Buffalo was routed 30–13 by Miami.
• Prediction: Josh Allen and the Bills should respond at home after an ugly loss. Expect a balanced offensive rebound.
• Pick: Bills 27, Buccaneers 20
• Best Bet: Buffalo -5.5 | Lean: Under 49.5

Houston Texans @ Tennessee Titans

• 12:00 AM ET | FOX | Nashville, TN
• Line: HOU -7.5 | O/U: 38.5
• Last Week: Houston topped Jacksonville 36-29; Tennessee rested.
• Prediction: Davis Mills is quietly consistent, and the Texans’ offense has rhythm. Titans won’t match Houston’s pace.
• Pick: Texans 26, Titans 14
• Best Bet: Houston -7.5 | Lean: Over 38.5

Chicago Bears @ Minnesota Vikings

• 12:00 AM ET | FOX | Minneapolis, MN
• Line: MIN -2.5 | O/U: 45.5
• Last Week: Chicago edged NYG 24-20; Minnesota lost 27–19 to Baltimore.
• Prediction: Chicago’s young offense continues to gain confidence, while Minnesota struggles to close games.
• Pick: Bears 24, Vikings 23
• Best Bet: Chicago +2.5 | Lean: Over 45.5

Green Bay Packers @ New York Jets

• 12:00 AM ET | FOX | East Rutherford, NJ
• Line: GB -8.5 | O/U: 44.5
• Last Week: Jets beat Cleveland 27-20; Packers rested.
• Prediction: The Jets have improved, but Green Bay’s extra rest and experience should prevail on the road.
• Pick: Packers 27, Jets 17
• Best Bet: Green Bay -8.5 | Lean: Under 44.5

Cincinnati Bengals @ Pittsburgh Steelers

• 12:00 AM ET | CBS | Pittsburgh, PA
• Line: PIT -5.5 | O/U: 50.5
• Last Week: Pittsburgh fell 25-10 to LAC; Bengals rested.
• Prediction: The Steelers are fading fast offensively, while a rested Bengals squad has the edge.
• Pick: Bengals 24, Steelers 20
• Best Bet: Cincinnati +5.5 | Lean: Under 50.5

Los Angeles Chargers @ Jacksonville Jaguars

• 12:00 AM ET | CBS | Jacksonville, FL
• Line: LAC -2.5 | O/U: 44.5
• Last Week: Chargers beat Pittsburgh 25-10; Jags lost 36–29 to Houston.
• Prediction: Justin Herbert is playing efficiently, and the Jaguars’ secondary continues to leak yards.
• Pick: Chargers 28, Jaguars 23
• Best Bet: LAC -2.5 | Lean: Over 44.5

Seattle Seahawks @ Los Angeles Rams

• 3:05 AM ET | FOX | Inglewood, CA
• Line: LAR -2.5 | O/U: 48.5
• Last Week: Seattle beat Arizona 44-22; Rams stunned San Francisco 42–26.
• Prediction: Two hot offenses meet in what could be a shootout. Expect the Rams’ momentum to carry at home.
• Pick: Rams 30, Seahawks 27
• Best Bet: LAR -2.5 | Lean: Over 48.5

San Francisco 49ers @ Arizona Cardinals

• 3:05 AM ET | FOX | Glendale, AZ
• Line: SF -2.5 | O/U: 48.5
• Last Week: The 49ers were blown out by LA; Arizona was handled by Seattle.
• Prediction: San Francisco rebounds behind Christian McCaffrey and George Kittle.
• Pick: 49ers 31, Cardinals 21
• Best Bet: SF -2.5 | Lean: Over 48.5

Baltimore Ravens @ Cleveland Browns

• 3:25 AM ET | CBS | Cleveland, OH
• Line: BAL -9.5 | O/U: 41.5
• Last Week: Baltimore beat Minnesota 27-19; Cleveland fell to the Jets.
• Prediction: The Ravens are rolling, and Cleveland’s offense lacks firepower to keep up.
• Pick: Ravens 27, Browns 13
• Best Bet: Baltimore -9.5 | Lean: Under 41.5

Kansas City Chiefs @ Denver Broncos

• 3:25 AM ET | CBS | Denver, CO
• Line: KC -3.5 | O/U: 44.5
• Last Week: Denver edged Las Vegas 10-7; Chiefs rested.
• Prediction: Denver’s defense stays tough, but Patrick Mahomes will find ways to win late.
• Pick: Chiefs 24, Broncos 17
• Best Bet: Kansas City -3.5 | Lean: Under 44.5

Detroit Lions @ Philadelphia Eagles

• 7:20 AM ET | NBC, Peacock | Philadelphia, PA
• Line: PHI -1.5 | O/U: 48.5
• Last Week: Detroit crushed Washington 44-22; Eagles rested.
• Prediction: The Lions’ offense is clicking behind Jared Goff and Jahmyr Gibbs. Expect a road upset.
• Pick: Lions 30, Eagles 27
• Best Bet: Detroit +1.5 | Lean: Over 48.5

Dallas Cowboys @ Las Vegas Raiders (Monday, November 17, 2025)

• 7:15 PM ET | ABC, ESPN | Allegiant Stadium, NV
• Line: DAL -3.5 | O/U: 50.5
• Last Week: Raiders fell 10-7 to Denver; Cowboys rested.
• Prediction: Dallas comes off the bye refreshed and ready. Dak Prescott and CeeDee Lamb should take over against a flat Raiders defense.
• Pick: Cowboys 28, Raiders 17
• Best Bet: Dallas -3.5 | Lean: Under 50.5

Week 11 brings several pivotal matchups that could reshape the playoff race – especially Lions vs Eagles and Dolphins vs Commanders in Madrid. The Ravens, Patriots, and Texans look like solid locks this week, while Detroit could deliver the biggest statement win on the road.