Las Vegas Raiders vs Denver Broncos Week 10 Prediction, Odds, and Picks
The Denver Broncos return home after five straight wins and will host the struggling Las Vegas Raiders on Thursday Night Football. Denver enters as a strong favorite (-9) according to BetMGM, while Las Vegas is desperate to snap a two-game losing streak and keep its season alive.
Las Vegas Raiders vs Denver Broncos Preview (Week 10, 2025 NFL Season)
- Date: Thursday, November 6, 2025
- Time: 8:15 PM ET
- TV: Amazon Prime Video
- Venue: Empower Field at Mile High, Denver, CO
- Moneyline: Raiders +360 | Broncos -475
Las Vegas Raiders (3–6)
The Raiders have lost four of their last five games, including a heartbreaking 30–29 loss to Jacksonville. Rookie quarterback Aidan O’Connell was placed on injured reserve with a wrist injury, leaving veteran backup play as their only option. Offensive line injuries—especially losing Kolton Miller—make things worse for a unit already ranked 29th in scoring (16.5 PPG).
- Injuries: Aidan O’Connell (Wrist – IR), Kolton Miller (Ankle – IR), Lonnie Johnson Jr. (Fibula – IR)
- Offense: 302.8 yards per game (28th), 41.2% 3rd down conversion (19th)
- Defense: Allows 26.3 points per game (23rd), 16 sacks (24th)
Denver Broncos (7–2)
The Broncos are on fire, riding a five-game win streak capped by a gritty 18–15 victory over the Houston Texans. Their defense has been the story, ranking 4th in points allowed (18.4 PPG) and 1st in sacks (40). Even with injuries to top defenders like Pat Surtain II and P.J. Locke, Denver’s pass rush and run defense have dominated opponents.
- Injuries: Pat Surtain II (Pectoral – Out), Marvin Mims Jr. (Concussion – Out), P.J. Locke (Neck – Out)
- Offense: 25.0 PPG (14th), 133.6 rushing YPG (7th)
- Defense: 279.9 YPG allowed (3rd), 93.1 rush YPG allowed (8th)
Matchup Breakdown
| Category | Raiders | Broncos |
| Points per Game | 16.5 | 25 |
| Points Allowed per Game | 26.3 | 18.4 |
| Total Offense | 302.8 YPG | 353.1 YPG |
| Total Defense | 333.4 YPG | 279.9 YPG |
| Sacks | 16 | 40 |
Denver dominates both trenches-its pass rush should easily collapse the Raiders’ depleted offensive line. The Raiders’ defense will struggle to contain Denver’s balanced attack led by an improving run game and solid quarterback play.
Prediction & Betting Pick
The Raiders are overmatched in this AFC West clash. Denver’s defense is elite, and the offense has enough balance to control the tempo at home. Unless Las Vegas can create turnovers, it’s hard to see them keeping it close.
- Pick Against the Spread: Broncos -9
- Over/Under: Under 42 (expect Denver’s defense to smother Vegas)
- Moneyline: Broncos (-475)
Final Score Prediction:
Denver Broncos 27, Las Vegas Raiders 13