NFL Week 10 Picks and Predictions (2025 Season)

Week 10 of the 2025 NFL season brings playoff-level intensity as several marquee matchups could reshape division races. Fans can look forward to the international showdown in Berlin, where the red-hot Colts meet the unpredictable Falcons, and a primetime clash at Lambeau Field between the Eagles and Packers.

Among the most challenging and must-watch games this week:

• Buffalo at Miami (CBS, 1:00 PM ET): A high-powered AFC East duel with major playoff implications.
• Rams at 49ers (FOX, 4:25 PM ET): A fierce NFC West rivalry that’s always physical and unpredictable.
• Eagles at Packers (ABC/ESPN, Monday 8:15 PM ET): Jalen Hurts faces the elements and Jordan Love in a potential postseason preview.
• Steelers at Chargers (NBC, 8:20 PM ET): Two defensive-minded squads meet in a key AFC primetime test.

Let’s break down every game, matchup by matchup, with predictions and best picks.

Thursday, November 6

Las Vegas Raiders @ Denver Broncos

• 9:15 PM ET | Prime Video
• Empower Field at Mile High, Denver, CO
• Line: DEN -10.5 | O/U: 41.5
• Prediction: Broncos 27, Raiders 14
• Pick: Denver -10.5

Why: Denver’s defense continues to roll, forcing turnovers while Russell Wilson finds rhythm against a soft Raiders secondary.

Sunday, November 9

Atlanta Falcons vs Indianapolis Colts (Germany Game)

• 9:30 AM ET | NFL Network / NFL+
• Olympic Stadium, Berlin
• Line: IND -5.5 | O/U: 48.5
• Prediction: Colts 30, Falcons 24
• Pick: Indianapolis -5.5 | Over 48.5

Why: Anthony Richardson’s dual-threat ability shines overseas, while the Colts’ defense limits Bijan Robinson late.

New York Giants @ Chicago Bears

• 1:00 PM ET | FOX
• Soldier Field, Chicago, IL
• Line: CHI -3.5 | O/U: 48.5
• Prediction: Bears 26, Giants 20
• Pick: Chicago -3.5

Why: Caleb Williams stays composed at home. Chicago’s front seven pressures Daniel Jones into mistakes.

Buffalo Bills @ Miami Dolphins

• 1:00 PM ET | CBS
• Hard Rock Stadium, Miami Gardens, FL
• Line: BUF -8.5 | O/U: 50.5
• Prediction: Bills 33, Dolphins 23
• Pick: Buffalo -8.5 | Over 50.5

Why to Watch: Josh Allen vs. Tua Tagovailoa in a potential AFC playoff preview. Buffalo’s defense has the edge in the heat.

Baltimore Ravens @ Minnesota Vikings

• 1:00 PM ET | FOX
• U.S. Bank Stadium, Minneapolis, MN
• Line: BAL -3.5 | O/U: 48.5
• Prediction: Ravens 28, Vikings 24
• Pick: Minnesota +3.5 (Cover)

Why: Lamar Jackson makes enough plays to win, but the Vikings’ crowd noise and Kirk Cousins keep it close.

Cleveland Browns @ New York Jets

• 1:00 PM ET | CBS
• MetLife Stadium, East Rutherford, NJ
• Line: NYJ -2.5 | O/U: 36.5
• Prediction: Jets 17, Browns 13
• Pick: Jets -2.5 | Under 36.5

Why: Expect a defensive slugfest. Aaron Rodgers relies on short passes to avoid Cleveland’s pass rush.

New England Patriots @ Tampa Bay Buccaneers

• 1:00 PM ET | CBS
• Raymond James Stadium, Tampa, FL
• Line: TB -2.5 | O/U: 48.5
• Prediction: Buccaneers 27, Patriots 21
• Pick: Tampa Bay -2.5

Why: The Bucs’ offensive balance with Rachaad White and Mike Evans outpaces the Patriots’ conservative approach.

New Orleans Saints @ Carolina Panthers

• 1:00 PM ET | FOX
• Bank of America Stadium, Charlotte, NC
• Line: CAR -4.5 | O/U: 39.5
• Prediction: Panthers 20, Saints 17
• Pick: Saints +4.5 | Under 39.5

Why: Bryce Young finds just enough offense, but this NFC South duel remains low scoring.

Jacksonville Jaguars @ Houston Texans

• 1:00 PM ET | CBS
• NRG Stadium, Houston, TX
• Line: HOU -1.5 | O/U: 37.5
• Prediction: Texans 23, Jaguars 20
• Pick: Houston -1.5 | Under 37.5

Why: C.J. Stroud continues his rise as Houston strengthens its AFC South claim.

Arizona Cardinals @ Seattle Seahawks

• 4:05 PM ET | CBS
• Lumen Field, Seattle, WA
• Line: SEA -7.5 | O/U: 44.5
• Prediction: Seahawks 31, Cardinals 17
• Pick: Seattle -7.5 | Over 44.5

Why: Geno Smith thrives at home; Arizona’s defense has no answer for Metcalf and Lockett.

Los Angeles Rams @ San Francisco 49ers

• 4:25 PM ET | FOX
• Levi’s Stadium, Santa Clara, CA
• Line: LAR -3.5 | O/U: 50.5
• Prediction: 49ers 28, Rams 27
• Pick: 49ers +3.5 | Over 50.5

Why to Watch: A classic NFC West rivalry. McCaffrey and Puka Nacua headline a high-octane battle that could swing the division.

Detroit Lions @ Washington Commanders

• 4:25 PM ET | FOX
• Northwest Stadium, Landover, MD
• Line: DET -7.5 | O/U: 50.5
• Prediction: Lions 34, Commanders 21
• Pick: Detroit -7.5 | Over 50.5

Why: Jared Goff’s offense remains efficient while Washington’s defense continues to falter.

Pittsburgh Steelers @ Los Angeles Chargers

• 8:20 PM ET | NBC / Peacock
• SoFi Stadium, Inglewood, CA
• Line: LAC -3.5 | O/U: 44.5
• Prediction: Chargers 27, Steelers 20
• Pick: Los Angeles -3.5 | Over 44.5

Why to Watch: A defensive chess match between T.J. Watt and Joey Bosa. Herbert’s arm strength proves decisive.

Monday, November 10

Philadelphia Eagles @ Green Bay Packers

• 8:15 PM ET | ABC / ESPN
• Lambeau Field, Green Bay, WI
• Line: GB -2.5 | O/U: 44.5
• Prediction: Eagles 24, Packers 21
• Pick: Philadelphia +2.5 | Under 44.5

Why to Watch: One of the most challenging games of the week. Jalen Hurts faces cold-weather conditions against a resurgent Jordan Love in a possible NFC playoff showdown.

Note: Odds by ESPN BET