NFL Week 6 Game-By-Game Odds & Predictions
Check out the complete NFL Week 6 odds breakdown every matchup from Thursday to Monday Night Football for the 2025 season. Fans can catch every matchup live across Prime Video, CBS, FOX, NBC, ESPN, and NFL Network. For streaming, tune in via NFL+, YouTube TV, or your local provider.
Philadelphia Eagles (-7.5) @ New York Giants
The Eagles are favored by more than a touchdown, showing oddsmakers’ confidence in Philadelphia’s offense and overall balance. The Giants are home but still big underdogs — Eagles are clearly expected to win.
Denver Broncos (-7.5) @ New York Jets
Denver enters as a strong favorite by 7.5 points. The Jets’ struggles on offense make the Broncos the clear pick — Broncos are expected to win comfortably, even playing overseas in London.
Indianapolis Colts (-6.5) vs Arizona Cardinals
The Colts are solid favorites at home, with a near-touchdown spread. Arizona’s defense has been inconsistent, so Indianapolis is expected to control this game.
Los Angeles Chargers (-4.5) @ Miami Dolphins
The Chargers are favored by 4.5 points, suggesting sportsbooks expect a close but decisive win. With Justin Herbert’s passing attack clicking, Chargers are slightly favored to win.
New England Patriots (-3.5) @ New Orleans Saints
The Patriots are narrow favorites on the road, indicating confidence in their defense and coaching edge. New England is expected to pull out a tight win.
Pittsburgh Steelers (-4.5) vs Cleveland Browns
With Pittsburgh favored by 4.5, the odds lean toward a home win. The Steelers’ defense gives them the edge — Pittsburgh expected to take it.
Dallas Cowboys (-3.5) @ Carolina Panthers
Dallas is a field-goal favorite on the road. The Panthers’ inconsistency makes Cowboys the better pick to win in this one.
Jacksonville Jaguars (-1.5) vs Seattle Seahawks
This line is almost even, but the Jaguars are slight favorites at home. Expect a competitive game — Jacksonville has the small edge according to sportsbooks.
Los Angeles Rams (-7.5) @ Baltimore Ravens
The Rams are heavy 7.5-point favorites, signaling confidence in their form. If the offense keeps firing, Rams should win handily despite playing away.
Las Vegas Raiders (-4.5) vs Tennessee Titans
The Raiders are favored by 4.5, suggesting oddsmakers expect them to defend home field. Las Vegas expected to win, though Titans could keep it close.
Green Bay Packers (-14.5) vs Cincinnati Bengals
The biggest spread of the week — Packers favored by two touchdowns. That’s a huge vote of confidence for Green Bay at home — Packers heavily expected to win.
Tampa Bay Buccaneers (-2.5) vs San Francisco 49ers
A tight line but home advantage tips it toward Tampa Bay. Buccaneers slightly favored to win in a close one.
Kansas City Chiefs (-1.5) vs Detroit Lions
A near pick’em game, but the Chiefs’ experience at Arrowhead gives them the edge. Kansas City is narrowly favored to win Sunday night.
Buffalo Bills (-3.5) @ Atlanta Falcons
Buffalo is a field-goal favorite, showing more trust in Josh Allen and their explosive offense. Bills expected to win, but Falcons could challenge.
Washington Commanders (-4.5) vs Chicago Bears
Washington is favored at home, backed by a stronger defense and quarterback play. Commanders expected to win, with a modest margin.
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