2025-2026 San Francisco 49ers Schedule
The San Francisco 49ers will begin their 2025 NFL regular season in September. It will their 76th season in National Football League history. The 49ers played as a NFC West division opponents are Cardinals, Seahawks and Rams. However, 49ers 2025-2026 NFL game schedule with time, date, TV channel, location, and scores are available here.
| Date | Opponent | Arena | Time | Tv |
| Sunday Sep. 7 | at Seattle Seahawks | Lumen Field, Seattle, WA | 4:05pm ET | FOX |
| Sunday Sep. 14 | at New Orleans Saints | Caesars Superdome, New Orleans, LA | 1:00pm ET | FOX |
| Sunday Sep. 21 | Arizona Cardinals | Levi’s Stadium, Santa Clara, CA | 4:25pm ET | FOX |
| Sunday Sep. 28 | Jacksonville Jaguars | Levi’s Stadium, Santa Clara, CA | 4:05pm ET | FOX |
| Thursday Oct. 2 | at Los Angeles Rams | SoFi Stadium, Inglewood, CA | 8:15pm ET | Prime Video |
| Sunday Oct. 12 | at Tampa Bay Buccaneers | Raymond James Stadium, Tampa, FL | 1:00pm ET | CBS |
| Sunday Oct. 19 | Atlanta Falcons | Levi’s Stadium, Santa Clara, CA | 8:20pm ET | NBC |
| Sunday Oct. 26 | at Houston Texans | NRG Stadium, Houston, TX | 1:00pm ET | FOX |
| Sunday Nov. 2 | at New York Giants | MetLife Stadium, East Rutherford, NJ | 1:00pm ET | CBS |
| Sunday Nov. 9 | Los Angeles Rams | Levi’s Stadium, Santa Clara, CA | 4:25pm ET | FOX |
| Sunday Nov. 16 | at Arizona Cardinals | State Farm Stadium, Glendale, AZ | 4:05pm ET | FOX |
| Monday Nov. 24 | Carolina Panthers | Levi’s Stadium, Santa Clara, CA | 8:15pm ET | ESPN |
| Sunday Nov. 30 | at Cleveland Browns | Cleveland Browns Stadium, Cleveland, OH | 1:00pm ET | CBS |
| Sunday Dec. 7 | BYE | |||
| Sunday Dec. 14 | Tennessee Titans | Levi’s Stadium, Santa Clara, CA | 4:25pm ET | FOX |
| Monday Dec. 22 | at Indianapolis Colts | Lucas Oil Stadium, Indianapolis, IN | 8:15pm ET | ESPN |
| Sunday Dec. 28 | Chicago Bears | Levi’s Stadium, Santa Clara, CA | 8:20pm ET | NBC |
| Sunday Jan. 4 | Seattle Seahawks | Levi’s Stadium, Santa Clara, CA | Time TBA | TBA |
Please Note: 2025-2026 San Francisco 49ers schedule is subject to be changed according to the official updates.