2025 NFL Week 12 Picks & Predictions
Week 12 arrives with the NFC standings tightening at the top and several playoff hopefuls fighting to stay alive. Philadelphia and the LA Rams both sit at 8-2, Chicago is climbing at 7-3, and teams like Seattle, Green Bay, and San Francisco continue to pressure the leaders. Meanwhile, bubble teams such as Detroit and Carolina need every win they can get.
Below is the full Week 12 game slate in ET time, with analysis and predictions for each matchup.
Buffalo vs Houston – 7:15 PM ET (Prime Video)
Line: Buffalo -3.5 | Total: 43.5
Buffalo has been more consistent offensively, while Houston relies heavily on defensive stands at home. Buffalo’s balance and better red-zone efficiency give them the slight edge.
- Pick: Buffalo wins and covers
- Score Prediction: Bills 24, Texans 20
Sunday, Nov 23 (ET)
Pittsburgh vs Chicago – 12:00 PM ET (CBS)
Line: Chicago -3 | Total: 45.5
Chicago enters on a three-game win streak and sits 7-3 in the NFC playoff picture. At home, they’ve protected Soldier Field well. Pittsburgh’s offense hasn’t matched their physical defense.
- Pick: Chicago wins a close one
- Score Prediction: Bears 23, Steelers 20
New England vs Cincinnati – 12:00 PM ET (CBS)
Line: New England -7 | Total: 50.5
New England being favored on the road tells you everything: Cincinnati has struggled badly. New England’s defense should control the pace.
- Pick: New England wins comfortably
- Score Prediction: Patriots 27, Bengals 17
New York Jets vs Detroit – 12:00 PM ET (FOX)
Line: DET-11.5O/U49.5
Detroit is trying to climb out of the “Out” column in the NFC standings (6-4, L-1). The Jets have lacked consistency all season. At home in Ford Field, Detroit has a major advantage.
- Pick: Detroit wins
- Score Prediction: Lions 26, Jets 19
Minnesota vs Green Bay – 12:00 PM ET (FOX)
Line: Green Bay -6.5 | Total: 41.5
Minnesota’s 1-4 recent stretch shows how cold they’ve become. Green Bay, meanwhile, has won three of its last five and is positioned firmly in the NFC playoff race.
- Pick: Green Bay wins and covers
- Score Prediction: Packers 24, Vikings 13
Seattle vs Tennessee – 12:00 PM ET (FOX)
Line: Seattle -13 | Total: 41.5
Seattle (7-3) is the clear superior team and Tennessee is out of the playoff picture. A large spread, but deserved.
- Pick: Seattle wins big
- Score Prediction: Seahawks 30, Titans 10
Indianapolis vs Kansas City – 12:00 PM ET (CBS)
Line: Kansas City -3.5 | Total: 49.5
At home, Kansas City is far more explosive. Indianapolis can move the ball but struggles against elite QBs.
- Pick: Kansas City wins
- Score Prediction: Chiefs 28, Colts 23
New York Giants vs Baltimore – 12:00 PM ET (CBS)
Line: Baltimore -14.5 | Total: 44.5
The Giants sit 2-9 and on a five-game losing streak. Baltimore dominates mismatches like this.
Pick: Baltimore wins easily
Score Prediction: Ravens 31, Giants 14
Cleveland vs Las Vegas – 3:05 PM ET (CBS)
Line: Las Vegas -3 | Total: 37.5
Low-total defensive game. Cleveland struggles with passing offense, while Vegas has found some rhythm recently at home.
- Pick: Las Vegas wins
- Score Prediction: Raiders 20, Browns 16
Jacksonville vs Arizona – 3:05 PM ET (CBS)
Line: Jacksonville -2.5 | Total: 47.5
Arizona (3-7, L-2) has fallen apart lately. Jacksonville’s offense should take control late.
- Pick: Jacksonville wins and covers
- Score Prediction: Jaguars 27, Cardinals 21
Philadelphia vs Dallas – 3:25 PM ET (FOX)
Line: PHI-4.5O/U50.5
Philadelphia leads the NFC at 8-2 with a four-game win streak. Dallas is near the bottom (3-5-1, L-2) and simply can’t match the Eagles’ strength on either side.
- Pick: Philadelphia wins
- Score Prediction: Eagles 30, Cowboys 20
Atlanta vs New Orleans – 3:25 PM ET (FOX)
Line: Atlanta -1.5 | Total: 39.5
Both teams are deep in the “Out” column. Atlanta has lost five straight, while New Orleans finally broke their losing streak. Momentum leans slightly NO.
- Pick: New Orleans pulls the upset at home
- Score Prediction: Saints 21, Falcons 17
Tampa Bay vs Los Angeles Rams – 7:20 PM ET (NBC/Peacock)
Line: Rams -6.5 | Total: 49.5
This is a key NFC matchup. The Rams (8-2, W-5) are the hottest team in the conference. Tampa Bay (6-4, L-2) is sliding fast. LA’s offense at home has been nearly unstoppable.
- Pick: Rams win and cover
- Score Prediction: Rams 31, Buccaneers 24
Monday, Nov 24
Carolina vs San Francisco – 7:15 PM ET (ESPN)
Line: San Francisco -7 | Total: 47.5
San Francisco (7-4) is gaining momentum again, while Carolina (6-5) is still inconsistent. At home, SF has a significant advantage.
- Pick: San Francisco wins
- Score Prediction: 49ers 28, Panthers 20
Week 12 offers multiple crucial NFC games – especially Eagles-Cowboys, Rams-Buccaneers, and 49ers-Panthers. Top seeds have a chance to create separation, while several fringe teams face potential elimination scenarios.