2025-2026 San Francisco 49ers Schedule
The San Francisco 49ers are scheduled to begin their 2025 NFL regular season against the Seattle Seahawks on September 7 at Lumen Field, Seattle, WA. The 49ers played as a NFC West division, and opponents are Cardinals, Seahawks and Rams. However, 49ers 2025-2026 NFL game schedule with time, date, TV channel, location, and scores are available here.
When is 49ers next game?
49ers next game is set for a NFL regular season Week 3 game against the Arizona Cardinals on Sunday, September 21, 2025 at Levi’s Stadium, Santa Clara, CA.
What time does it air?
- Time: 4:25 PM ET
- TV: FOX
Where do San Francisco 49ers their home game?
San Francisco 49ers play their home game at Levi’s Stadium, Santa Clara, CA.
2025-2026 San Francisco 49ers Regular Season
| Week | Date | Opponent | Time ET | TV | Result |
| 1 | Sunday Sep. 7 | at Seattle Seahawks | Final | FOX | W (17-13) |
| 2 | Sunday Sep. 14 | at New Orleans Saints | 1:00pm | FOX | TBA |
| 3 | Sunday Sep. 21 | Arizona Cardinals | 4:25pm | FOX | TBA |
| 4 | Sunday Sep. 28 | Jacksonville Jaguars | 4:05pm | FOX | TBA |
| 5 | Thursday Oct. 2 | at Los Angeles Rams | 8:15pm | Prime Video | TBA |
| 6 | Sunday Oct. 12 | at Tampa Bay Buccaneers | 1:00pm | CBS | TBA |
| 7 | Sunday Oct. 19 | Atlanta Falcons | 8:20pm | NBC | TBA |
| 8 | Sunday Oct. 26 | at Houston Texans | 1:00pm | FOX | TBA |
| 9 | Sunday Nov. 2 | at New York Giants | 1:00pm | CBS | TBA |
| 10 | Sunday Nov. 9 | Los Angeles Rams | 4:25pm | FOX | TBA |
| 11 | Sunday Nov. 16 | at Arizona Cardinals | 4:05pm | FOX | TBA |
| 12 | Monday Nov. 24 | Carolina Panthers | 8:15pm | ESPN | TBA |
| 13 | Sunday Nov. 30 | at Cleveland Browns | 1:00pm | CBS | TBA |
| 14 | Sunday Dec. 7 | BYE | |||
| 15 | Sunday Dec. 14 | Tennessee Titans | 4:25pm | FOX | TBA |
| 16 | Monday Dec. 22 | at Indianapolis Colts | 8:15pm | ESPN | TBA |
| 17 | Sunday Dec. 28 | Chicago Bears | 8:20pm | NBC | TBA |
| 18 | Sunday Jan. 4 | Seattle Seahawks | TBD | TBA | TBA |
Future San Francisco 49ers Opponents
Please Note: 2025-2026 San Francisco 49ers schedule is subject to change according to the official updates.